The proximate values and pathological effects of the consumption of kolanuts were determined. A total of thirty albino rats aged 8-16 weeks were procured from the Animal House of Department of Biochemistry University of Nigeria Nsukka. LD50 was carried out using eighteen kmn albino rats within 14 days. Rats were divided into 3 groups A, B, and C. Group A were given 0.02g of Cola acuminata and Cola nitida paste daily while group B consumed 0.04g daily and group C (Control) were fed on pellets. Drinking water was given to both the control rats and experimental rats and libitum. Statistical analysis of the weight using student ‘t’ test for comparison of weight before experimentation and after showed significant decrease in rats weight P<0.05. The results obtained revealed normal liver tissues in control with normal parenchyma. However, the liver of rats exposed to kola nuts showed evidence of vacuolation, infiltration of inflammatory cells and mild to moderate necrosis as shown in the photomicrographs. The kidney tissues revealed the presence of casts in the tubular lumen, mild erosion of tubules and constriction of capillary turf. However, the proximate values of kolanuts revealed Moisture, Ash, Protein, Fat, Fibre, Carbohydrate and Calories.
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Ozoffor et al. (2024) studied this question.
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