IL‑18 binding protein (IL‑18BP) is a natural regulatory molecule of the proinflammatory cytokine IL‑18. It can regulate activity of IL‑18 by high affinity binding. The present review aimed to highlight developments, characteristics and functions of IL‑18BP. IL‑18BP serves biological and anti‑pathological roles in treating disease. In humans, it modulates progression of a number of chronic diseases, such as adult‑onset Still's disease. The present review summarizes molecular structure, role of IL‑18BP in disease and interaction with other proteins in important pathological processes.
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Feng-Xue Wang (2024) studied this question.
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