Disruption of DEPDC5 gene function has been linked to drug-resistant epilepsy in both, human and animal models. DEPDC5 is a negative regulator of nutrient signaling through mTOR. The ketogenic diet (KD) is a commonly prescribed therapy for drug-resistant epilepsy. The utility of KD for therapeutic treatment of DEPDC5-related epilepsies remains unknown.
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Gupta et al. (2024) studied this question.
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