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April 9, 2024Neurology

Measurement and Modeling of Peripherally Administered Anti-CGRP Monoclonal Antibody in CSF and Brain of Healthy Volunteers (S22.006)

Jacki Rorabaugh Juline Bryson Edward T. Hellriegel Andrijana Radivojevic Or Dotan Giulia Ghibellini Hang Zeng Xiaofeng Lu Fangteng Dai Thelma S. Angeles Olga Szilagy James Wang Stephen Mallett Steve Barash Laura Rabinovich‐Guilatt Peter J. Goadsby Andrew Ahn

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Abstract

To estimate the potential distribution and target engagement of a monoclonal antibody (mAb) to calcitonin-gene related peptide (CGRP) in the cerebrospinal fluid (CSF) and brain interstitial fluid (ISF).

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Rorabaugh et al. (2024) studied this question.

synapsesocial.com/papers/68e6fcb5b6db643587676ebf https://doi.org/10.1212/wnl.0000000000205261

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