In the current study, we analyzed genotype and multimodal MRI data from participants in the UK Biobank (N~ 23 000) and Adolescent Brain Cognitive Development Study (N~ 4660), to assess associations of genetic loading for AD with multiple MRI metrics of the whole brain. We also investigated these associations in children and adults by using two cognitively normal populations spanning wide age ranges, as the neural mechanisms during adolescence may vary from those during adulthood.
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He et al. (2024) studied this question.
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