Spatiotemporal control of catalytic DNAzyme activity has been achieved in the Research Article (e202404064) by Lele Li, Mengyuan Li et al. Molecular weaving activatable DNAzyme into the skeleton of tetrahedral DNA nanocages not only enables efficient intracellular delivery with improved biostability, but also allows for light-triggered on-demand liberation of DNAzyme and thus conditional control of catalytic gene regulation function.
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Zhao et al. (2024) studied this question.
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