Optimization of the antifungal properties of the bacterial peptide EntV by variant analysis

Shantanu Guha; Shane A. Cristy; Giuseppe Buda De Cesare; Melissa R. Cruz; Michael Lorenz; Danielle A. Garsin

doi:10.1128/mbio.00570-24

April 8, 2024mBioOpen Access

Optimization of the antifungal properties of the bacterial peptide EntV by variant analysis

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Key Points

Variant analysis optimizes the antifungal properties of bacterial peptide EntV, addressing the growing public health threat posed by fungal resistance.
Optimization of bacterial peptide EntV targets fungal resistance to commonly used medicines, which creates a dire need to develop new classes of antifungals.
Analysis of peptide variants supports the development of new antifungals, highlighting potential approaches to overcome antimicrobial resistance mechanisms.

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Implication

Variant analysis demonstrates optimization of antifungal properties of bacterial peptide EntV, highlighting potential strategies against fungal resistance.

Abstract

Fungal resistance to commonly used medicines is a growing public health threat, and there is a dire need to develop new classes of antifungals. We previously described a peptide produced by

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Guha et al. (2024) studied this question.

synapsesocial.com/papers/68e6ffe7b6db64358767999f https://doi.org/10.1128/mbio.00570-24

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Optimization of the antifungal properties of the bacterial peptide EntV by variant analysis

Key Points

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Implication

Abstract

Discussion

Cite This Study

Optimization of the antifungal properties of the bacterial peptide EntV by variant analysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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