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September 10, 2025International Journal of Molecular SciencesOpen Access

In Silico and In Vitro Potential Antifungal Insights of Insect-Derived Peptides in the Management of Candida sp. Infections

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Authors

CSCatarina SousaASAlaka SahooSSShasank S. Swain

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Overview

In silico evaluations reveal insect-derived peptides show potential against Candida sp., suggesting new treatments.

Key Points

  • In silico results indicate that Blap-6 and Gomesin exhibit strong binding abilities against Candida sp.
  • Gomesin achieved complete biofilm eradication in three out of four Candida species, indicating effectiveness.
  • Molecular docking and dynamics simulations supported peptide interactions with key fungal targets for drug development.
  • The study highlights the potential of insect-derived peptides as alternatives for antifungal treatments against Candida sp.

Cite This Study

Sousa et al. (2025) studied this question.

synapsesocial.com/papers/68c1b61454b1d3bfb60eb546https://doi.org/10.3390/ijms26157449
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