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This study aims to explore how the PepGAT peptide affects Candida albicans, particularly its mechanisms of action.

June 15, 2026Scientific ReportsOpen Access

Unraveling the mechanism of action of the PepGAT peptide against Candida albicans through proteomics approaches

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Randomized trial evaluates PepGAT's impact on C. albicans, suggesting new antifungal alternatives.

This study aims to explore how the PepGAT peptide affects Candida albicans, particularly its mechanisms of action.
Utilized proteomic analysis to assess protein profiles in C. albicans cells.
Conducted enzymatic activity assays and membrane permeability assessments.
Studied ergosterol interactions to evaluate effects on membrane integrity.
PepGAT altered protein profiles, affecting pathways related to development and drug resistance.
Decreased superoxide dismutase activity and increased catalase activity were observed.
Inhibition of ergosterol biosynthesis was noted, leading to the potential formation of membrane pores.

Gomes et al. (2026) studied this question.

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