Molecular analysis reveals impaired lymphocyte differentiation following defective CARD11 expression, indicating an NF-κB-independent pathway for thymic Treg development.
CARD11 is a lymphoid lineage-specific scaffold protein regulating the NF-κB activation downstream of the antigen receptor signal pathway. Defective CARD11 function results in abnormal development and differentiation of lymphocytes, especially thymic regulatory T cells (Treg).
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Hu et al. (2024) studied this question.
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