Supplementary Figure S1 from Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment

Anatomical image of peritoneal MMs (white long arrows) induced by chronic intraperitoneal injections of chrysotile in a Bap1+/- mouse. MMs developing in Bap1+/- and Bap1+/+ (wild type) littermates injected with either chrysotile or crocidolite generally were diffuse peritoneal lesions sometimes accompanied by ascites. Note that the MMs shown in this animal are unusually large for illustrative purposes. Most tumors in this model were solitary, much smaller, and diffuse. Irregular liver surface (yellow rectangle) is likely indicative of fibrosis. L, liver; LI, large intestine; M, mesothelioma.