Supplementary Figure S4 from Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment

Tumor immune microenvironment of chrysotile-induced MM from a Bap1+/- mouse. Serial sections of MM stained with several different immune cell markers: CD3 (T cells), CD45R (B cells), F4/80 (macrophages), and NK1.1 (natural killer cells), clockwise starting from upper left. T, B, and NK cells are depleted in tumor, whereas numerous cells in and around the tumor are stained with the macrophage marker F4/80.