A New Sesquiterpene from the Fungus Penicillium sp. LPFH-hzw-zw1

An investigation of the secondary metabolites of the sea sediment-derived Penicillium sp.LPFH-ZW-1 resulted in the identification of a new compound, named penicipeneacid (1), along with seven known compounds.The structures of these compounds were established by extensive analysis of the 1D and 2D NMR data, combined with HRESIMS data.The absolute configuration of 1 was determined by comparing the experimental and predicted ECD spectra.The bicyclo[4.1.0]heptanenucleus in compounds 1 and 2 was rarely found in nature.The known compounds were identified to be sesquicaranoic acid B (2), 9-cycloneren-3,7,11triol (3), fumiquinazoline J (4), versiquinazoline H (5), penipurdin A (6), questinol (7), and 2-hydroxy-4ethoxybenzoic acid (8).Compounds 4 and 7 exhibited moderate cytotoxicity against MCF-7 and K562 tumor cell lines, with IC50 values ranging from 12.6 to 37.1 M.