Vaccine development relies heavily on the identification of appropriate antigen targets to induce robust immune responses. Traditional methods for vaccine target identification often involve laborious experimental procedures and may lack scalability. In recent years, Machine Learning, has emerged as a viable alternative for bioinformatics tasks, including vaccine target identification. In this paper, we present an implementation of Machine Learning -based approaches for vaccine target identification and provide insights into their effectiveness. We utilize a comprehensive dataset of pathogen proteins and employ Machine Learning for feature analysis and prediction. Our results demonstrate the promising performance of Machine Learning models in accurately identifying vaccine targets, showcasing their efficiency and interpretability. Through a detailed analysis, we highlight the key factors influencing model performance and discuss potential avenues for further improvement. Overall, our study underscores the potential of Machine Learning - based approaches in vaccine target identification, offering valuable insights for future research in the field.
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Gandotra et al. (2024) studied this question.
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