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The present investigation aims at a histopathological assessment of the potential ameliorating effects of stem cells and rutin against acute renal toxicity by acetaminophen in male rats. Two main experiments were conducted using seventy rats. Twenty immature rats were used in the primary investigation as a source of bone marrow. In the second investigation, fifty mature rats were split into two groups: G (1) served as the control group, and G (2) received 750 mg/kg b.w./72 hours of oral acetaminophen (APAP) for three weeks. This group was divided into four subgroups: (A) rats receiving APAP for three weeks, then left for two months without treatment; (B) rats receiving APAP for three weeks, followed by treatment with rutin (RUT) (25 mg/kg b.w./d) for two months; (C) rats receiving APAP for three weeks, then the rats were injected in their tail vein by mesenchymal cells (MS) (1.5x 106 cells in 0.5 PBS) for two months; and (D) rats received APAP for three weeks, then MS injected in the tail vein, and received RUT for two months. After taking tissue sections of the kidneys: it was found that the rats receiving APAP alone had perivascular edema with blood vessel congestion, tubular deterioration, glomerulus deteriorating lesions, and inflammatory cell penetration in their renal tissues. Whereas the APAP RUT and APAP-MS-RUT groups showed few tubular deteriorations. Moreover, APAP MS displayed the typical kidney histological structure. The results of the investigation showed that MS significantly lowers acute renal toxicity. Keywords: kidney; rutin; histopathology; mesenchymal cell; acetaminophen.
EL-Dab et al. (Sat,) studied this question.