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Laboratory study reveals cadmium activates placental mitophagy by downregulating thyroid hormone receptor and PGC1α signaling in preeclampsia, highlighting a potential pathway in placental disease.
Gestational cadmium exposure increases the risk of preeclampsia. Placenta mitophagy was activated in preeclampsia. The aim of present study was to explore the mechanism of cadmium-induced mitophagy activation and its association with preeclampsia. Mitophagy markers expression levels were detected by quantitative real-time PCR, Western blot, immunofluorescence and immunochemistry in preeclampsia placenta. JEG3 cells were treated with CdCl
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Yu et al. (2024) studied this question.
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