The Influence of Sleep on Brain Health

Sleep plays a crucial role in maintaining brain health and cognitive function. It is well-known that disrupted sleep is a common symptom of Alzheimer's disease (AD). However, emerging evidence suggests that even suboptimal sleep can increase the risk of developing AD. The deacetylase Sirtuin 1 (Sirt 1), which is encoded by the SIRT1 gene, has been found to influence sleep by affecting wake-sleep neurotransmitters and somnogens. Both animal and human studies have provided support for a complex relationship between sleep, Sirt 1/SIRT1, and AD. Various hypotheses have been proposed to explain the significant impact of Sirt 1/SIRT1 on neurons involved in promoting wakefulness and sleep, as well as their associated mechanisms and neurotransmitters. However, there is a lack of research investigating the interaction between sleep and Sirt 1/SIRT1 as a key component of sleep regulation in relation to AD pathology. In this review, we aim to explore the potential association between Sirt 1/SIRT1, sleep, and the development of AD. Considering that sleep is a modifiable risk factor for AD and recent studies suggest that the activation of Sirt 1/SIRT1 can be influenced by lifestyle and dietary interventions, further research in this area is necessary to investigate its potential as a target for the prevention and treatment of AD.