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April 3, 2024The Journal of Clinical PsychiatryOpen Access

Serotonin Syndrome and Dextromethorphan Toxicity Caused by Drug-Drug Interaction Between Fluoxetine and Bupropion-Dextromethorphan

Michelle Anjali Singh Devon Johnson

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Abstract

Addition of bupropion-dextromethorphan (BUP/DXM) to existing fluoxetine treatment resulted in serotonin syndrome within 3 days, with symptoms prompting presentation to the ED 5 days after discontinuation of BUP/DXM.

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Singh et al. (2024) studied this question.

synapsesocial.com/papers/68e708c9b6db6435876823ca https://doi.org/10.4088/jcp.23cr15139

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