April 3, 2024Frontiers in OncologyOpen Access

Integrated analysis of scRNA-seq and bulk RNA-seq reveals that GPRC5A is an important prognostic gene in pancreatic cancer and is associated with B-cell Infiltration in pancreatic cancer

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Authors

CDChunlu DongFirst Hospital of Lanzhou University HMHaidong MaNingbo University NMNingning MiInner Mongolia Agricultural University

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Implication

Integrated transcriptomic analysis reveals elevated GPRC5A expression linked to B-cell infiltration in pancreatic cancer, highlighting its potential utility as a therapeutic target.

Key Points

GPRC5A exhibits substantial overexpression in pancreatic cancer tissue and correlates with reduced patient survival, while also associating positively with B-cell infiltration.
Cox and Lasso regression analyses identified a three-gene prognostic model from TCGA data, and quantitative RT-PCR assays successfully authenticated target gene expression levels.
Highlights GPRC5A as an independent prognostic risk factor in pancreatic cancer, indicating that this receptor represents a viable molecular target for developing novel therapies.

Cite This Study

Dong et al. (2024) studied this question.

synapsesocial.com/papers/68e708e0b6db643587682d7c https://doi.org/10.3389/fonc.2024.1283164

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Implication

Integrated transcriptomic analysis reveals elevated GPRC5A expression linked to B-cell infiltration in pancreatic cancer, highlighting its potential utility as a therapeutic target.

Integrated analysis of scRNA-seq and bulk RNA-seq reveals that GPRC5A is an important prognostic gene in pancreatic cancer and is associated with B-cell Infiltration in pancreatic cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Integrated analysis of scRNA-seq and bulk RNA-seq reveals that GPRC5A is an important prognostic gene in pancreatic cancer and is associated with B-cell Infiltration in pancreatic cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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