Background: Hyperammonemia caused by high-dose infusion of 5-fluorouracil (5-Fu) is a rare adverse reaction in patients with rectal cancer. There are very few reports of hyperammonemia caused by 5-Fu in domestic and foreign literatures, however, deficiency of DihydroPyrimidine Dehydrogenase (DPD) and the influence of 5-Fu metabolites may be the pathogenic mechanisms of encephalopathy. Muscle loss, renal insufficiency and infection also has played an important role in the occurrence.
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Jin et al. (2024) studied this question.
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