Experimental study demonstrates that ivacaftor attenuates gentamicin-induced ototoxicity via CFTR-Nrf2 signaling, suggesting a novel therapy for drug-induced hearing loss.
Objectives Gentamicin is one of the most common ototoxic drugs that can lower patients' quality of life. Oxidative stress is a key factors inducing sensory hair cell death during gentamicin administration. So far, there are no effective drugs to prevent or treat gentamicin- induced hearing loss. A recent study found cystic fibrosis transmembrane conductance regulator (CFTR) as a new target to modulate cellular oxidative balance. The objective of this study was to estimate the effect of the CFTR activator ivacaftor on gentamicin-induced ototoxicity and determine its mechanism.
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Hu et al. (2024) studied this question.
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