Synthesis of 3‐Aryl Substituted Triimidazotriazines via Regioselective Direct Arylation

A general and convenient selective direct arylation of the 3‐position of triimidazo[1,2‐a:1’,2’‐c:1’’,2’’‐e][1,3,5]triazine ( 1 ) with (hetero)aryl halides in DMA was successfully achieved in the presence of K 2 CO 3 as the base and a catalyst precursor consisting of Pd(OAc) 2 and P(2‐furyl) 3 . Electron‐poor and ‐rich (hetero)aryl moieties, including the strongly deactivated and sterically encumbered 2,4,6‐trimethoxyphenyl unit, are well tolerated in the electrophilic partner. The data obtained in this synthetic study support a reaction mechanism involving an electrophilic attack of an arylpalladium‐(II) halide species onto the triazine ring.