Supplementary Figure 10 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Transmission electron microscopy demonstrates that 25 nM QC6352 treatment for 72 hours caused a structural change resulting in less compact nucleoli WiT49 and HEK293 cells. More compact nucleoli with dense/compact fibrillar centers are known to be more active. Nuclear membranes indicated with black arrows and nucleoli are labeled.