Supplementary Figure 13 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Knockdown of KDM4A alters QC6352 sensitivity. (A) The PrestoBlue assay demonstrated that siRNA-mediated knockdown of KDM4A and C was associated with resistance to QC6352 when compared to parental cells and empty vector control in WiT49. (B) The PrestoBlue assay demonstrated that siRNA-mediated knockdown of KDM4A was associated with resistance to QC6352 when compared to parental cells and empty vector control in HEK293. (C)IC50 values for WiT49 and HEK293 with siKDM4A-C and NTC siRNA.