Figure S2 from The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Robert W. Robey; Christina M. Fitzsimmons; Wilfried M. Guiblet; William J.E. Frye; José M. González Dalmasy; Li Wang; Drake A. Russell; Lyn M. Huff; Andrew J. Perciaccante; Fatima Ali-Rahmani; Crystal C. Lipsey; Heidi M. Wade; Allison V. Mitchell; Siddhardha S. Maligireddy; David Terrero; Donna Butcher; Elijah F. Edmondson; Lisa M. Jenkins; Tatiana Nikitina; Victor B. Zhurkin; Amit K. Tiwari; Anthony D. Piscopio; Rheem A. Totah; Susan E. Bates; H. Efsun Arda; Michael M. Gottesman; Pedro J. Batista

doi:10.1158/1535-7163.25523507.v1

Key Points

MCF7 DpVp300 cell lines demonstrate pronounced resistance to romidepsin, an established thiol-based histone deacetylase inhibitor.
Cell cycle analysis and cytotoxicity data confirm romidepsin resistance while showing that these cells do not overexpress P-gp transport proteins.
Findings highlight non-P-gp mechanisms underlying resistance linked to methyltransferases; cell culture model requires further preclinical work.

Implication

In vitro analysis demonstrates romidepsin resistance without P-gp overexpression in MCF7 DpVp300 cells, suggesting alternative drug resistance pathways.

Abstract

Figure S2 contains cell cycle analysis and cytotoxicity data for MCF7 DpVp300 cells showing they are resistant to romidepsin and do not overexpress P-gp

Discussion

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Cite This Study

Robey et al. (2024) studied this question.

synapsesocial.com/papers/68e70c5ab6db643587685ef1 https://doi.org/10.1158/1535-7163.25523507.v1

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Figure S2 from The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S2 from The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Key Points

Implication

Abstract

Discussion

Cite This Study

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