Figure S4 from Multiomic-Based Molecular Landscape of FaDu Xenograft Tumors in Mice after a Combinatorial Treatment with Radiation and an HSP90 Inhibitor Identifies Adaptation-Induced Targets of Resistance and Therapeutic Intervention

Supplemental Figure S4: Heat Shock protein gene expression was significantly modified by treatment over time. Statistical difference (2-fold change, p < 0.01) indicated with (*). No radiation samples showed statistically significant changes compared to time-matched Untreated tumors, though there was a trend towards significant downregulation for HSPB11 and HSP90AA1 in Rad Week 2 samples compared to UT_Wk2. HSPA1A was significantly upregulated in Drug+Rad Week 1 and Week 2 samples compared to respective UT_Wk1 and 2 samples. HSPA1B was also upregulated in Drug and Drug+Rad at Week 1 and Week 2 compared to respective UT_Wk1 and UT_Wk2. HSP90AA1 was only significantly downregulated at Drug Week 2. For HSPB11 only Drug+Rad Week 1 and Week 2 were significantly downregulated. HSPA14 showed significant downregulation at Drug and Drug+Rad Week 1 and Drug Week 2 compared to respective controls.