April 1, 2024ACS Applied Nano Materials

GSH-Responsive Metal–Organic Framework-Based Nanoplatform for Combined Chemo–Chemodynamic Therapy

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Authors

SCSucheta ChatterjeeBhabha Atomic Research Centre ARArchita RaiBhabha Atomic Research Centre RPRaghavendra S. PatwardhanBhabha Atomic Research Centre

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Implication

Preclinical study demonstrates superior tumor suppression with a dual-action nanocomposite in mice, highlighting a versatile nanoplatform for combined chemo-chemodynamic therapy.

Key Points

A glutathione-responsive metal-organic framework nanoplatform achieved enhanced tumor suppression, coupling doxorubicin chemotherapy with reactive oxygen species generation.
In vitro assays in lung adenocarcinoma cells confirmed intracellular hydrogen peroxide production, glutathione depletion, and mitochondrial membrane potential disruption.
Combined chemo-chemodynamic therapy outpaced monotherapies in mouse tumor models, highlighting a customizable drug delivery platform; mouse model, further preclinical work needed.

Cite This Study

Chatterjee et al. (2024) studied this question.

synapsesocial.com/papers/68e70da3b6db6435876874b9 https://doi.org/10.1021/acsanm.4c00787

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Implication

Preclinical study demonstrates superior tumor suppression with a dual-action nanocomposite in mice, highlighting a versatile nanoplatform for combined chemo-chemodynamic therapy.

GSH-Responsive Metal–Organic Framework-Based Nanoplatform for Combined Chemo–Chemodynamic Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

GSH-Responsive Metal–Organic Framework-Based Nanoplatform for Combined Chemo–Chemodynamic Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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