Systematic review demonstrates increased risks of preeclampsia and maternal death in pregnant women with COVID-19, highlighting urgent need for clinical vigilance.
Objective: This systematic review aimed to analyze whether COVID-19 represents a risk factor for preeclampsia, preterm birth, maternal death, neonatal death, and admission of neonates to the Intensive Care Unit (NICU). Data Sources: Searches were performed in Embase, PubMed, and CENTRAL. Study Selection: Analytical observational studies whose subjects were pregnant women with confirmed COVID-19 were included. Data Extraction: Three reviewers extracted all relevant data from the studies selected for inclusion using a standardized form previously agreed upon by the team. Data pertaining to the studies and clinical outcomes were collected. Results: Twenty studies were included in the systematic review and the meta-analysis. Over 125.000 subjects were included, among them, over 5.000 positive for COVID-19. The meta-analysis showed a significant association between COVID-19 and preterm delivery and maternal death. It was also associated with cesarean delivery, preeclampsia/eclampsia, and emergency cesarean. Conclusion: Patients who are present with COVID-19 infection warrant careful clinical and obstetrical vigilance due to their higher risk of adverse outcomes and measures to reduce the risk for patients and fetuses.
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Carvalho et al. (2025) studied this question.
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