Accelerated Wound Closure in Neonatal Bart Syndrome with Negative Pressure Therapy: A Case Report

Bart Syndrome is a rare mechanobullous disorder and a subtype of epidermolysis bullosa (EB) that appears at birth with congenital localized absence of skin, absence or deformities of nails, and blistering of mucous membranes. Standard treatment reveals a variety of topical medical treatments with an average epithelization time of 3 months. Here, two newborn patients are presented with diagnosis of Bart Syndrome with significant EB and cutis aplasia on bilateral lower extremities. Both patients were successfully treated with Negative Pressure Wound Therapy (NPWT) and epithelization was achieved in only three weeks. This novel treatment underscores the importance of quick recovery time sin vulnerable neonatal populations and opens the door for further research to optimize NPWT for treatment of EB/Bart Syndrome.