Table S3 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia

Haley Newman; Shawn H.R. Lee; Petri Pölönen; Rawan Shraim; Yimei Li; Hongyan Liu; Richard Aplenc; Shovik Bandyopadhyay; Changya Chen; Meenakshi Devidas; Caroline Diorio; Kimberly P. Dunsmore; Omar Elghawy; Amira Elhachimi; Thomas Fuller; Sumit Gupta; Junior Hall; Andrew D. Hughes; Stephen P. Hunger; Mignon L. Loh; Zachary Martinez; Michael F. McCoy; Cassidy G. Mullen; Stanley Pounds; Elizabeth A. Raetz; Anna Eames Seffernick; Gongping Shi; Jonathan Sussman; Kai Tan; Lahari Uppuluri; Tiffaney L. Vincent; Ruth Wang’ondu; Lena E. Winestone; Stuart S. Winter; Brent L. Wood; Gang Wu; Jason Xu; Wenjian Yang; Charles G. Mullighan; Jun J. Yang; Kira Bona; David T. Teachey

doi:10.1158/2643-3230.30296497

Key Points

Genetic ancestry significantly affects survival outcomes in T-cell acute lymphoblastic leukemia, highlighting biological complexity.
Analysis revealing associations involves multinomial regression, utilizing TAL1 DP-like as the reference subtype for comparison.
Findings suggest that understanding genetic ancestry can improve tailored treatments for leukemia patients, potentially enhancing outcomes.
Study emphasizes the importance of incorporating genetic ancestry into models predicting survival in hematological malignancies.

Implication

Multinomial regression model analyzes genetic ancestry effects on survival outcomes in leukemia, indicating significance of biologic subtypes.

Abstract

Association of Genetic Ancestries (25% Interval) as Continuous Variables with Biologic Subtype (TAL1 DP-like as reference subtype) Using Multinomial Regression Model.

Discussion

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Cite This Study

Newman et al. (2025) studied this question.

synapsesocial.com/papers/68e70dab90569dd607ee5f55 https://doi.org/10.1158/2643-3230.30296497

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Table S3 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia

Key Points

Implication

Abstract

Discussion

Cite This Study

Table S3 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia

Key Points

Implication

Abstract

Discussion

Cite This Study

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