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October 9, 2025European Journal of Inorganic Chemistry

Zinc(II) and Copper(II) Binding of a MUC7 Peptide Fragment: Coordination, Thermodynamic Stability, and Antimicrobial Potency

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Authors

AKAlicja KrynickaUniversity of WrocławWLWojciech LizakUniversity of WrocławKSKlaudia SzarszońUniversity of Ljubljana

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Implication

This study reports the coordination of zinc and copper with a MUC7 peptide, indicating implications for metal ion roles in antimicrobial peptide function.

Key Points

  • Zinc coordination enhanced the antimicrobial activity of the MUC7-derived peptide slightly under alkaline conditions.
  • Cu(II) coordination did not significantly improve the peptide's antimicrobial properties or secondary structure.
  • The study analyzed complexes using electrospray ionization mass spectrometry and various spectroscopic methods.
  • These findings highlight the potential biological role of metal coordination in modulating antimicrobial peptides.

Cite This Study

Krynicka et al. (2025) studied this question.

synapsesocial.com/papers/68e70dab90569dd607ee6069https://doi.org/10.1002/ejic.202500263
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