Repeat Stereotactic Body Radiation Therapy for Spinal Metastases: Long-Term Outcomes and Toxicity

Suchet Taori; Samuel Adida; Serah Choi; Travis J. McCaw; Steven A. Burton; John C. Flíckinger; Roberta K. Sefcik; Peter C. Gerszten

doi:10.1227/neu.0000000000003772

October 7, 2025Neurosurgery

Repeat Stereotactic Body Radiation Therapy for Spinal Metastases: Long-Term Outcomes and Toxicity

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Key Points

Repeat SBRT yielded local control rates of 96%, 85%, and 77% at 6 months, 1 year, and 2 years, confirming its effectiveness.
Overall survival rates were 69%, 53%, and 35% at 6 months, 1 year, and 2 years, associated with previous cEBRT and patient age.
Clinical improvement in pain was noted in 95%, 82%, and 75% of treatments at 3, 6, and 12 months, indicating strong symptomatic relief.
The cumulative incidence of vertebral compression fractures was 6%, 20%, and 25% at the respective timeframes, with no observed radiation neuropathy.

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Implication

This analysis reveals improved local control and overall survival after repeat SBRT in patients with spinal metastases, suggesting its role in managing treatment failure.

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Taori et al. (2025) studied this question.

synapsesocial.com/papers/68e70db290569dd607ee60bb https://doi.org/10.1227/neu.0000000000003772

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Repeat Stereotactic Body Radiation Therapy for Spinal Metastases: Long-Term Outcomes and Toxicity

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Repeat Stereotactic Body Radiation Therapy for Spinal Metastases: Long-Term Outcomes and Toxicity

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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