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October 9, 2025Journal of Clinical MedicineOpen Access

Mutational Spectrum and Clinical Outcomes of Myelodysplastic/Myeloproliferative Neoplasms: A Single-Institution Study in Korea with Emphasis on U2AF1

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Authors

MPMin‐Seung ParkDCDae-Ho ChoiJJJun Ho Jang

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Overview

Retrospective analysis reveals U2AF1 mutations and overall survival trends in MDS/MPN patients.

Key Points

  • U2AF1 mutations were identified as a significant prognostic factor, indicating potential adverse outcomes.
  • ASXL1 mutations were found in 52.8% of patients, with a significant association with better prognosis in CMML cases.
  • Transfusion dependency was linked to poor prognosis, with a hazard ratio of 7.78, highlighting its clinical importance.
  • The study provides insights into the mutational spectrum and prognosis of MDS/MPNs based on Korean patient data.

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68e70db290569dd607ee60cdhttps://doi.org/10.3390/jcm14197074
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genomic Landscape of Myelodysplastic/Myeloproliferative Neoplasms: A Multi-Central Study2024 · 7 citations
  2. 2Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms2020 · 185 citations
  3. 3Myelodysplastic/myeloproliferative overlap neoplasms: Clinicopathological features, treatment strategies, and outcomes — a UK multicentre cohort Study2025
  4. 4Prognostic stratification in MDS/MPN syndromes other than CMML: an Italian multicenter real-world study2026
  5. 5Association between gene mutations and certain blood cell indices in patients diagnosed with myelodysplastic neoplasms2024