Experiment shows that dexpanthenol reduces inflammation and apoptosis in brain injury from chest trauma, suggesting its potential as a treatment.
Objective: Chest trauma-induced brain injury (CTB) occurs as a result of the formation of inflammatory markers in the lung and blood. Vitamin B5, derived from dexpanthenol (DEX), has antioxidant, anti-inflammatory, and antiapoptotic properties. This study aimed to investigate the protective effects of DXP on CTB. Materials and methods: Forty Wistar Albino males were divided into four groups as sham, CTB (Dropping a 200g weight from a height of 1 meter onto the anterior chest wall), CTB+DXP (500mg/kg, ip), and DXP. After 48 hours, rats were sacrificed under anesthesia, and the brain tissues were put into 10% formaldehyde solution for histopathological and immunohistochemical examination. Results: In the CTB group, rats exhibited significant hemorrhage, increased TNF-α, Cas-3, and decreased MBP expressions in the brain compared to the control group. DXP treatment significantly reducted hemorrhage areas and reversed immunoexpressions. Conclusion: CTB may develop in brain tissue by causing inflammation, apoptosis, and myelin sheath damage. These adverse effects can be reversed with DXP treatment.
No takes yet. Share an insight, caveat, or question.
Taşan et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: