Observational analysis found higher free water fraction in Alzheimer disease, suggesting distinct spatiotemporal progression patterns impacting neuroanatomic signatures.
Juxtacortical free water fraction, determined at diffusion MRI, was higher in participants with Alzheimer disease compared with cognitively normal controls and associated with amyloid-β, tau, and neurodegeneration biomarkers, revealing two distinct spatiotemporal progression patterns with different impacts on neuroanatomic signatures and cognitive performance.
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Zhang et al. (2025) studied this question.
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