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October 9, 2025Journal of the American Association for Laboratory Animal Science

Serum Pharmacokinetics of a Highly Concentrated Buprenorphine Formulation in Older Female Sprague–Dawley Rats (Rattus norvegicus)

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Authors

KGKristopher G. GalangHKHeather K. KnychRORhonda S Oates

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Overview

Animal study shows that a highly concentrated buprenorphine formulation achieves analgesic levels in older female rats, suggesting substantial pain management potential.

Key Points

  • Administration of the highly concentrated buprenorphine formulation achieves mean serum levels of 13.79 ng/mL after 0.5 hours.
  • At 12 hours post-administration, serum concentrations remained above the analgesic threshold, averaging 2.12 ng/mL.
  • Only a minor injection site reaction was noted, with no other known side effects from opioid administration observed.
  • The study supports HCB's ability to maintain buprenorphine levels for up to 24 hours in some rats, enhancing pain management efficacy.

Cite This Study

Galang et al. (2025) studied this question.

synapsesocial.com/papers/68e70db790569dd607ee67efhttps://doi.org/10.30802/aalas-jaalas-24-124
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