April 1, 2024Current Opinion in ImmunologyOpen Access

Mapping and modelling human B cell maturation in the germinal centre

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Single cell genomics and spatial genomics uncover diverse human germinal centre B cell states, providing new resolution for tracking antigen-driven immune responses.
Review of experimental culture systems assesses current laboratory platforms, evaluating their capacity to faithfully recreate authentic germinal centre B cell maturation.
Combining cell atlas mapping with lymphoid tissue modelling may enable functional validation of bioinformatic predictions, clarifying mechanisms of autoimmune diseases.

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Implication

Review reveals advances in mapping germinal centre B cell states in humans, highlighting the need for experimental culture models to test genomic predictions.

Cite This Study

Quig et al. (2024) studied this question.

synapsesocial.com/papers/68e71035b6db643587689abe https://doi.org/10.1016/j.coi.2024.102428

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Implication

Review reveals advances in mapping germinal centre B cell states in humans, highlighting the need for experimental culture models to test genomic predictions.

Mapping and modelling human B cell maturation in the germinal centre

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Discussion

Implication

Cite This Study

Mapping and modelling human B cell maturation in the germinal centre

Key Points

Discussion

Implication

Cite This Study

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