Wcn24-1673 Uncommon Cause of Steroid-Resistant Nephrotic Syndrome, Case Report

Nephrotic syndrome (NS) is the most common primary glomerulopathy in children. Only 10% are steroid-resistant (SRNS), being more frequent in patients over 12 years of age. The main histopathology in SRNS in children is focal segmental glomerular sclerosis (FSGS), followed by minimal change disease (MCD) and diffuse mesangial sclerosis. Membranous glomerulonephritis (MGN) is detected in less than 1% of cases. In children, 50% of primary membranous GN present anti-PLA2R. Early detection of anti-PLA2R in patients with SRNS has diagnostic value and defines treatment response.