We report multiple cases of gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS), all within the same family. Esophagogastroduodenoscopy of a 29-year-old woman revealed a pedunculated large polyp, along with fundic gland polyposis. Endoscopic resection was performed on the large polyp, leading to the pathologic diagnosis of pyloric gland adenoma. A mutation in the promoter 1B region of the APC gene was found, leading to a diagnosis of GAPPS. GAPPS is a rare disease, and its pathogenesis remains unknown. In this case series, the clinical course of GAPPS is presented with detailed endoscopic findings during a long-term follow-up.
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Hirai et al. (2024) studied this question.
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