Biochemical effect of aluminum chloride induced brain damage in mice

Neurotoxicity is commonly associated with the central and/or peripheral nerve systems structural damage. It happens when a chemical interferes with the normal functioning of the nervous system, potentially resulting in the death of neurons transmitting and informationprocessing. The purpose of this study was to investigate the effect of aluminum chloride (AlCl₃) induced neurotoxicity in mice. Forty mice were allocated into two equal groups. Group 1(Normal control), which fed a regular laboratory diet for four weeks. Group 2 (Aluminum chloride) rats received AlCl₃ orally at a dose of (8.5 mg/kg/day) for four weeks. The obtained results revealed a significant increase in brain tissue amyloid beta, nitric oxide and in serum cortisol, complement C3 and C4 concentrations, while brain tissue SOD and CAT activities were markedly decreased in AlCl₃ treated mice as compared with normal control. In conclusion, AlCl₃ has toxic and harmful effects with noticeable oxidative stress and inflammation.