Murine study reveals Purslane oil extract reduces worm burden and egg loads in Schistosoma mansoni infection, suggesting therapeutic value against resistant parasites.
Schistosomiasis is a neglected tropical illness, relying on a single drug to treat, its efficacy decreasedas drug resistant strains emerged due to widespread usage. The study evaluated thetherapeutic and prophylactic effects of Purslane (Portulaca oleracea) oil extract in comparisonto praziquantel (PZQ) on experimental S. mansoni-infected mice by measuring parasitological,antioxidant activity, immunological, and histopathological parameters. Mice were infected followedby a single oral dose of PZQ or daily Purslane oil extract for 15 days, six weeks postinfection.Purslane treated group induced significant reduction in mean worm burden, hepatic,and intestinal egg loads, serum levels of ALT, AST along with significant rise in CAT,SOD,GSH-R, GPx activities, TNF- α, IL-4, IL-10, dead eggs percentage, and moderate decreasein granuloma diameter. PZQ was more effective than purslane. Purslane's methanol extracthas promising therapeutic but little prophylactic effects against S. mansoni.
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MOSTAFA et al. (2024) studied this question.
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