Design and Evaluation of Ketorolac Tromethamine Drug Loaded Mucilage-Alginate Based Microspheres

The present study was started with aim to utilize natural mucilage for sustained delivery of drug.Linum usitatissimum mucilage was selected to formulate drug loaded microspheres.Ketorolac tromethamine (KTM) and Erythriana Indica (EI) microspheres were selected to formulate mucilage-alginate based microspheres.They showed acceptable particle diameter and good stability as predicted from surface charge.The microspheres were formulated, coloaded with drug & evaluated for physical examination, swelling index.The drug content in the microspheres were evaluated using FTIR and DSC.Thus, formulated microspheres could be promising alternative as mucoadhesive novel drug delivery system.