April 1, 2024European PsychiatryOpen Access

Hyperammonemic encephalopathy in a 46 year old patient treated with valproic acid as treatment for borderline personality disorder: a case report.

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Valproic acid therapy induced reversible hyperammonemic encephalopathy presenting with lethargy and impaired consciousness in a 46-year-old individual, resolving after drug withdrawal.
Case report and literature review indicate that valproic acid cessation serves as primary intervention, frequently supported by lactulose or carnitine administration.
Highlights the vital need for clinicians to screen for hyperammonemia in patients with unexplained altered mental status to ensure timely treatment and reduce hospitalization.

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Implication

Case report reveals valproic acid-induced hyperammonemic encephalopathy in borderline personality disorder, highlighting the need for prompt recognition and therapy cessation.

Cite This Study

Preciados et al. (2024) studied this question.

synapsesocial.com/papers/68e712a7b6db64358768b4ba https://doi.org/10.1192/j.eurpsy.2024.1449

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Implication

Case report reveals valproic acid-induced hyperammonemic encephalopathy in borderline personality disorder, highlighting the need for prompt recognition and therapy cessation.

Hyperammonemic encephalopathy in a 46 year old patient treated with valproic acid as treatment for borderline personality disorder: a case report.

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Implication

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Hyperammonemic encephalopathy in a 46 year old patient treated with valproic acid as treatment for borderline personality disorder: a case report.

Key Points

Discussion

Implication

Cite This Study

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