Comparative Agreement of a New Spectral-Domain OCT Biometer, Swept-Source OCT Biometer, and OLCR Biometer: A Comprehensive Analysis of Ocular Biometer in Healthy Eyes.

Background: With the advancements in ocular biometric technology, there have been significant improvements in accurately and efficiently measuring ocular parameters. The aim of this study is to compare the reliability of biometric parameters obtained using a new frequency-domain optical coherence tomography (SD-OCT) biometer with the measurements obtained from swept-source OCT (SS-OCT) and optical low coherence reflectometry (OLCR) biometers. Methods: The Colombo IOL (Moptim, Shenzhen, China) employs SD-OCT technology, the IOLMaster 700 (Carl Zeiss Meditec AG, Jena, Germany) utilizes SS-OCT technology, and the SW-9000 (Suoer, Tianjin, China) utilizes OLCR technology. This cross-sectional study compared the measurement of biometric parameters using a novel SD-OCT biometer with SS-OCT and OLCR biometers. The study adhered to ethical guidelines and obtained informed consent. The findings will enhance our understanding of the accuracy and reliability of the SD-OCT biometer, benefiting clinical practice and future research. Results: 146 eyes from 73 healthy subjects were analyzed. The IOLMaster 700 and Colombo IOL showed a high correlation for AL, CCT, K1, and K2, with Pearson's correlation coefficients of 0.99, 0.99, 0.99, and 0.98, respectively. Bland-Altman plots indicated a strong agreement between the two instruments for AXL and CCT measurements. These findings confirm the reliability of the Colombo IOL in assessing biometric parameters. Conclusions： The new SD-OCT biometer and the SS-OCT biometer showed strong agreement in measuring AL, CCT, K1, and K2 in healthy subjects, indicating their effective interchangeability in clinical practice. This supports the reliability of the new SD-OCT biometer as an alternative for assessing these parameters. Further research is needed to explore their applicability in different clinical settings and patient populations.