Supplementary Figure S11 from Development of a [⁸⁹Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library

Supplementary Figure 11. Specific uptake of the [89Zr]Zr-DFO-L111 in tumors in vivo. Bar graph showing the uptake of the [89Zr]Zr-DFO-Isotype or [89Zr]Zr-DFO-L111 at days 2 and 5 in nude mice bearing A549 tumors in the hindlimb (n=4). Tumors were irradiated with three doses of 3Gy over 24h, followed by injection with radiolabeled antibodies. Cold anti-TIP1 Ab was injected before injecting the radiolabeled for the blocking study. Bar graphs represent %ID/gm. *P<0.05, **P<0.01