Wcn24-2151 Effect of Inhibition of the KHK Enzyme by Ostol on Renal Mitochondrial Damage in a Model of Metabolic Syndrome

Nowadays metabolic syndrome (MS) cases are growing worldwide. Evidence shows that diet plays an important role in the MS development, being the western diet is the best example. This diet is characterized by a high consumption of Fructose, leading to hyperuricemia, cardiovascular damage, oxidative stress, inflammation, hypertension, inducing glomerular filtration rate decrease and renal disease. Fructose induces these metabolic effects primarily from the nucleotide degradation that results following metabolism of fructose by the C isoform of KHK, that lacks a negative feedback mechanism, thus depleting ATP levels by the fast fructose phosphorylation.