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September 10, 2025Molecular and Cellular EndocrinologyOpen Access

Mitochondrial dysfunction and defective quality control mechanisms in the kidney are not reversed by high-fat diet withdrawal in early obese mice

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Mitochondrial dysfunction was evident in kidneys after high-fat diet, with impaired bioenergetics not fully reversed by dietary withdrawal.
Reduced expression of PGC-1α and alterations in several mitochondrial dynamics proteins were noted after high-fat diet exposure in the kidneys.
Proteomic analysis identified significant changes in glutathione metabolism and fatty acid oxidation related proteins due to high-fat diet.
The findings highlight the role of mitochondrial integrity and potential therapeutic strategies for managing kidney disease progression.

Authors

PBPatrícia C. BragaUniversidade do Porto RVRui VitorinoUniversidade do Porto RFRita FerreiraRede de Química e Tecnologia

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Implication

Observational analysis reveals persistent mitochondrial dysfunction and altered metabolism in kidneys, suggesting dietary changes alone do not fully restore health.

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Braga et al. (2025) studied this question.

synapsesocial.com/papers/68c1b80c54b1d3bfb60ebc56 https://doi.org/10.1016/j.mce.2025.112635

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Implication

Observational analysis reveals persistent mitochondrial dysfunction and altered metabolism in kidneys, suggesting dietary changes alone do not fully restore health.

Mitochondrial dysfunction and defective quality control mechanisms in the kidney are not reversed by high-fat diet withdrawal in early obese mice

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Discussion

Implication

Cite This Study

Mitochondrial dysfunction and defective quality control mechanisms in the kidney are not reversed by high-fat diet withdrawal in early obese mice

Key Points

Discussion

Implication

Cite This Study

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