Key result
High-fat diet accelerates myocardial mitochondrial dysfunction by ~11 months in ob/ob mice versus regular chow.
Why the study?
The impact of diet and age on myocardial mitochondrial function and metabolic profiles in ob/ob mice compared to wild-type mice was not fully understood.
Does a high-fat diet accelerate age-related mitochondrial dysfunction in the hearts of ob/ob mice?
Population
ob/ob and wild-type mice across four age groups
Comparison
High-fat diet vs regular chow diet
Design
Preclinical metabolic profiling study
Follow-up
Up to 14 months
Authors
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Myocardial mitochondrial dysfunction in diabetic mouse models; leaves open human causality and therapeutic targeting.
Does a high-fat diet accelerate age-related mitochondrial dysfunction in the hearts of ob/ob mice?
A high-fat diet accelerates age-related myocardial mitochondrial dysfunction in ob/ob mice, likely due to increased oxidative damage and diacylglycerol accumulation rather than triglycerides or acylcarnitines.
Wang et al. (2015) studied Mitochondrial dysfunction and diabetic cardiomyopathy. High-fat diet (HFD) vs. Regular chow diet (RCD) was evaluated on Myocardial mitochondrial dysfunction. A high-fat diet in ob/ob mice accelerated myocardial mitochondrial dysfunction, making it detectable at 3 months compared to 14 months on a regular chow diet.
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