Why the study?
Does the ob/ob mutation (obesity) increase cardiac lipid accumulation and cause diastolic dysfunction in mice?
Population
Obese ob/ob mice and ob/+ mice
Comparison
ob/ob mutation (obesity model) vs ob/+ mice
Design
Preclinical
Authors
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Associates ob/ob obesity with cardiac steatosis and diastolic dysfunction in mice; leaves open human translation.
Does the ob/ob mutation (obesity) increase cardiac lipid accumulation and cause diastolic dysfunction in mice?
In a mouse model, obesity driven by the ob/ob mutation is associated with increased cardiac lipid accumulation and parallel diastolic dysfunction.
Christoffersen et al. (2003) studied this question.
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