Why the study?
Does central or peripheral leptin treatment normalize myocardial fatty acid oxidation in caloric-restricted ob/ob mice?
Does central or peripheral leptin treatment normalize myocardial fatty acid oxidation in caloric-restricted ob/ob mice?
Impaired hypothalamic leptin signaling increases myocardial fatty acid oxidation by increasing delivery of free fatty acid substrates to the heart, which can be normalized by central leptin administration.
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Findings in ob/ob mice do not alter clinical practice; hypothesis-generating for leptin-mediated cardiac metabolism in diabetes.
Sloan et al. (2011) studied this question.
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